Epinephrine is a chemical that narrows blood vessels and opens airways in the lungs. These effects can reverse severe, wheezing, severe skin itching,, and other symptoms of an allergic reaction. Adrenalin is used to treat severe () to insect stings or bites, foods, drugs, and other allergens. Epinephrine auto-injectors may be kept on hand for self-injection by a person with a history of severe allergic reaction. Adrenalin is for use in adults and children who weigh at least 16.5 pounds (7.5 kilograms). Epinephrine is also used to treat exercise-induced anaphylaxis, or to treat low blood pressure that is caused by septic shock. Adrenalin may also be used for purposes not listed in this medication guide.

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Before taking this medicine Before using epinephrine, tell your doctor if any past use of Adrenalin caused an allergic reaction to get worse. Tell your doctor if you have ever had: • heart disease or; •; •; • or mental illness; • a thyroid disorder; or • diabetes. Having an allergic reaction while pregnant or nursing could harm both mother and baby. You may need to use epinephrine during pregnancy or while you are breast-feeding. Seek emergency medical attention right away after using the injection. In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.

How should I use Adrenalin? Epinephrine is injected into the skin or muscle of your outer thigh. In an emergency, this injection can be given through your clothing.

Epinephrine is sometimes given as an infusion into a vein. A healthcare provider will give you this type of injection.

The auto-injector device is a disposable single-use system. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Do not give this medicine to a child without medical advice.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Do not remove the safety cap until you are ready to use the auto-injector. Never put your fingers over the injector tip after the safety cap has been removed. To use an epinephrine auto-injector: • Form a fist around the auto-injector with the tip pointing down.

Pull off the safety cap. • Place the tip against the fleshy portion of the outer thigh.

You may give the injection directly through clothing. Hold the leg firmly when giving this injection to a child or infant. • Push the auto-injector firmly against the thigh to release the needle that injects the dose of epinephrine. Hold the auto-injector in place for 10 seconds after activation. • Remove the auto-injector from the thigh and massage the area gently. Carefully re-insert the used device needle-first into the carrying tube.

Re-cap the tube and take it with you to the emergency room so that anyone who treats you will know how much epinephrine you have received. • Use an auto-injector only one time. Do not try to reinsert an auto-injector a second time if the needle has come out of your skin before the full 10 seconds.

If the needle is bent from the first use, it may cause serious injury to your skin. Seek emergency medical attention after any use of epinephrine. The effects of epinephrine may wear off after 10 or 20 minutes.

You will need to receive further treatment and observation. Do not use Adrenalin if it has changed colors or has particles in it, or if the on the label has passed. Call your pharmacist for a new prescription.

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